KONTINUIERLICHES VERFAHREN ZUR HERSTELLUNG VON PESTIZIDEN CHLORTHIAZOLEN

• Main Authors: DESPONDS, OLIVIER, PASSAFARO, MARCO, RAPOLD, THOMAS, FABER, DOMINIK
• Format: Patent
• Language: German
• Published: 20.10.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

There are described a process for the preparation of a compound of formula in free form or in salt form, wherein Q is CH or N; Y is NO2 or CN; Z is CHR3, O, NR3 or S; R1 and R2 are, for example, C1-C8alkyl or together form an alkylene bridge; R3 is H or C1-C12alkyl which is unsubstituted or substituted by R4; and R4 is unsubstituted or substituted aryl or heteroaryl; wherein a) a compound of formula wherein X is a leaving group, is reacted with a chlorinating agent to form a compound of formula in free form or in salt form; and b) the compound of formula (III) thereby obtained is reacted with a compound of formula wherein R1, R2, Y, Z and Q are as defined for compound (I); in which process the chlorination according to process step a) is performed in a continuous process; a process for the preparation of a compound of formula (III) according to process a) hereinbefore; and the use of the compounds of formulae (II), (III) and (IV) in a process as described hereinbefore.