Glycoprotein mit hemmender Aktivität gegen die Besiedlung von Helicobacter pylori

• Main Authors: KIMURA, NOBUTAKE, KODAMA, YOSHIKATSU
• Format: Patent
• Language: German
• Published: 04.08.2005
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; CHEWING GUM; COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; COMPOSITIONS THEREOF; CONFECTIONERY; CULTURE MEDIA; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; ICE-CREAM; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATION THEREOF; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

An inhibitor of Helicobacter pylori colonization in the stomach comprises as an active ingredient a glycoprotein which specifically binds to H. pylori urease. This glycoprotein is isolated and purified from a glycoprotein-containing substance, especially that derived from bovine milk whey or albumen of chicken eggs by affinity chromatography using a column on which H. pylori urease is immobilized. The glycoprotein is able to effectively inhibit H. pylori colonization, so is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers. A food and medicament comprising the inhibitor are also provided.