INDAZOL-VERBINDUNGEN UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ZUR HEMMUNG VON PROTEINKINASEN UND VERFAHREN ZU IHRER VERWENDUNG

• Main Authors: HUA, YE, LUU, HIEP THE, KANIA, ROBERT STEVEN, BENDER, STEVEN LEE, REICH, SIEGFRIED HEINZ, CRIPPS, STEPHAN JAMES, JOHNSON, THEODORE OTTO, BRAGANZA, JOHN F, VARNEY, MICHAEL DAVID, PALMER, CYNTHIA LOUISE, THOMAS, CHRISTINE, TENG, MIN, WALLACE, MICHAEL BRENNAN, COLLINS, MICHAEL RAYMOND, JOHNSON, MICHAEL DAVID, TEMPCZYK-RUSSELL, ANNA MARIA, BORCHARDT, ALLEN J
• Format: Patent
• Language: German
• Published: 14.02.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.