VERFAHREN ZUR HERSTELLUNG VON PYRAZOLO[1,5-B]PYRIDAZIN-DERIVATEN

• Main Authors: MATHEWS, NEIL, WARD, RICHARD A, WHITEHEAD, J
• Format: Patent
• Language: German
• Published: 29.12.2005
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A process for the preparation of a compound of formula (I)and pharmaceutically acceptable derivatives thereof in which:R is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR R ;R and R are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR R , (CH2)nSC1-6alkyl or C(O)NR R ; with the proviso that when R is at the 4-position and is halogen, at least one of R and R is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR R or (CH2)nSC1-6alkyl, C(O)NR R ;R is C1-6alkyl or NH2;R and R are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; andn is 1-4.