2,3-BENZODIAZEPINDERIVATE

• Main Authors: GIGLER, GABOR, SIMIG, GYULA, BARK CZY, JETAZSEF, MARTONN MARK, BERNADETT, SIM, ANNAMARIA, L VAY, GYOERGY, SZAB, GEZA, GREFF, ZOLTAN, TIHANYI, KAROLY, BLASK, GABOR, R TKAI, ZOLTAN, EGYED, ANDRAS
• Format: Patent
• Language: German
• Published: 29.04.2004
• Edition: 7

The invention relates to new 2,3-benzodiazepine derivatives of general Formula (I), (wherein R1 stands for methyl, formyl, carboxy, cyano, -CH-NOH, -CH-NNHCONH2 or -NR5R6, wherein R5 and R6 independently from each other represent hydrogen or lower alkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R2 is nitro or amino; R3 stands for hydrogen, lower alkanoyl or CO-NR7R8, wherein R7 and R8 independently from each other stand for hydrogen, lower alkoxy, lower alkyl or lower cycloalkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R4 is hydrogen or lower alkyl; the dotted lines have the following meaning: if R3 and R4 are not present, the bond between positions C8 and C9 is a single bond and the bond between positions C8 and N7 is a double bond; if R3 and R4 are present, the bonds between positions C8 and C9 and between position C8 and N7 are single bonds; and if R3 is present and R4 is missing, the bond between positions C8 and C9 is a double bond and the bond between positions C8 and N7 is a single bond) and salts thereof. The invention compounds have neuroprotective effect.