ANTIIMFLAMMATORISCHE INDOLDERIVATE
Therapeutic compounds of formula (I) wherein X is CH2 or SO2; R1 is an optionally substituted aryl or heteroaryl ring; R2 and R3 are various specified groups, R4 is a group NHCOR15, NHSO2R15 or OCONR16R17 where R15, R16 and R17 are various defined groups; and R5, R6 and R7 are independently selected...
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Main Authors | , |
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Format | Patent |
Language | German |
Published |
24.12.2003
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Therapeutic compounds of formula (I) wherein X is CH2 or SO2; R1 is an optionally substituted aryl or heteroaryl ring; R2 and R3 are various specified groups, R4 is a group NHCOR15, NHSO2R15 or OCONR16R17 where R15, R16 and R17 are various defined groups; and R5, R6 and R7 are independently selected from hydrogen, a functional group or an optionally substituted hydrocarbyl groups or optionally substituted heterocyclic groups; and further provided that when R4 is a group NHCOR15, R15 is substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; as well as pharmaceutical compositions containing them are described and claimed. These compounds and compositions are useful in the treatment of disease mediated by MCP-1 (monocyte chemoattractant protein-1) or RANTES (Regulated Upon Activation, Normal T-cell Expressed and Secreted), such as inflammatory disease. |
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Bibliography: | Application Number: DE20006001811T |