Process for the synthesis of 1-alkyl-3-hydroxy-5-halo-1,2,4-tri-azoles, and novel hydrazine derivatives

The invention relates to a process for the synthesis of 1-alkyl-3-hydroxy-5-halo-1,2,4-triazoles, which are intermediates in the synthesis of pesticides, by reaction of a 1-alkyl-3,5-dioxo-1,2,4-triazole with an ionic halogenating agent. The reaction is carried out in the presence of a nitrogen-cont...

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Bibliographic Details
Main Authors BONNARD, HUBERT, MAROLLES EN HUREPOIX, FR, LECOMTE, LOIC, VERT LE PETIT, FR, SENET, JEAN-PIERRE, LA CHAPELLE LA REINE, FR
Format Patent
LanguageEnglish
German
Published 17.11.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the synthesis of 1-alkyl-3-hydroxy-5-halo-1,2,4-triazoles, which are intermediates in the synthesis of pesticides, by reaction of a 1-alkyl-3,5-dioxo-1,2,4-triazole with an ionic halogenating agent. The reaction is carried out in the presence of a nitrogen-containing catalyst which is selected from amongst tertiary amines and their hydrohalides, heterocyclic amines and their hydrohalides, and the N,N-disubstituted amides. The 1-alkyl-3-hydroxy-5-halo-1,2,4-triazoles can be prepared from alkylhydrazines by the process according to the invention without use of the very toxic cyanogen halides. The invention further relates to 1-carbamoyl-1-isopropylhydrazine and the alkyl 2-carbamoyl-2-isopropylhydrazinecarboxylates, which are novel hydrazine derivatives.
Bibliography:Application Number: DE19944416868