Verfahren zur Herstellung von 1-[[2S]-(Methyl)-3-(mercapto)-propionyl]-pyrrolidin-[2S]-carbonsäure

The invention relates to a novel process for preparing 1-(/2S/-methyl-3-mercaptopropionyl)-pyrrolidine-/2S/-carboxylic acid of the formula I (* CHEMICAL STRUCTURE *) (I) in which 1-(/2S/-methyl-3-thiocyanatopropionyl)-pyrrolidine-/2S/-carboxylic acid of the formula II (* CHEMICAL STRUCTURE *) (II) i...

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Bibliographic Details
Main Authors BLASKO, GABOR., BUDAPEST, HU, SCHNEIDER, GEZA., BUDAPEST, HU, URMOES, GEB. LASSU, GABRIELLA, BUDAPEST, HU, BECK, IVAN., BUDAPEST, HU, DIETZ, ANDRAS, BUDAPEST, HU, KOVACS, GEB. PALOTAI, AGNES, BUDAPEST, HU, JAKFALVI, ELEMER, BUDAPEST, HU, DINNYES, GEB. NAGY, ILMA, BUDAPEST, HU
Format Patent
LanguageGerman
Published 07.03.1996
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a novel process for preparing 1-(/2S/-methyl-3-mercaptopropionyl)-pyrrolidine-/2S/-carboxylic acid of the formula I (* CHEMICAL STRUCTURE *) (I) in which 1-(/2S/-methyl-3-thiocyanatopropionyl)-pyrrolidine-/2S/-carboxylic acid of the formula II (* CHEMICAL STRUCTURE *) (II) is dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1-(/2S/-methyl-3-carbamoylthiopropionyl)-pyrrolidine-/2S/-carboxylic acid of the formula III (* CHEMICAL STRUCTURE *) (III) that forms is hydrolized with an aqueous solution of a base.
Bibliography:Application Number: DE19934307947