ANTISENSE-OLIGONUKLEOTIDE ZUR INHIBIERUNG DER TRANSAKTIVATORZIELSEQUENZ (TAR) UND DER SYNTHESE DES TRANSAKTIVATORPROTEINS (TAT) AUS HIV-1 UND DEREN VERWENDUNG

• Main Authors: LOEBBERDING, ANTONIUS. DR, PIEL, NORBERT. DR., 4006 ERKRATH, DE, KRETSCHMER, AXEL. DR., 5060 BERGISCH GLADBACH, DE, FROMMER, WERNER, DR., 5600 WUPPERTAL, DE, KOELBL, HEINZ. DR., WEST HAVEN, CONN., US, BAUMGARTEN, JOERG, STROPP, UDO-BIO.. DR., 5657 HAAN, DE, SPRINGER, WOLFGANG-BIOL. DR., 5600 WUPPERTAL, DE
• Format: Patent
• Language: German
• Published: 13.09.1990
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WINE

The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have antiviral effects. The pharmaceuticals can be used for the therapy of HIV infections. The antisense oligonucleotides are suitable as gene probes for detecting HIV.