ANTISENSE-OLIGONUKLEOTIDE ZUR INHIBIERUNG DER TRANSAKTIVATORZIELSEQUENZ (TAR) UND DER SYNTHESE DES TRANSAKTIVATORPROTEINS (TAT) AUS HIV-1 UND DEREN VERWENDUNG

The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have an...

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Main Authors LOEBBERDING, ANTONIUS. DR, PIEL, NORBERT. DR., 4006 ERKRATH, DE, KRETSCHMER, AXEL. DR., 5060 BERGISCH GLADBACH, DE, FROMMER, WERNER, DR., 5600 WUPPERTAL, DE, KOELBL, HEINZ. DR., WEST HAVEN, CONN., US, BAUMGARTEN, JOERG, STROPP, UDO-BIO.. DR., 5657 HAAN, DE, SPRINGER, WOLFGANG-BIOL. DR., 5600 WUPPERTAL, DE
Format Patent
LanguageGerman
Published 13.09.1990
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have antiviral effects. The pharmaceuticals can be used for the therapy of HIV infections. The antisense oligonucleotides are suitable as gene probes for detecting HIV.
Bibliography:Application Number: DE19893907562