Heterozyklische Spiroverbindungen und ihre Herstellung

Heterocyclic spiro compounds of formula @ @C represents a piperidine ring of which the nitrogene atom may have substituent(s) selected from alkyl, alkanoyl and alkoxycarbonyl and/or may be connected to a ring carbon (other than the common carbon atom of the spiro structure) via an alkylene bridging...

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Main Authors TAMURA, TOSHINARI, HASUNDA-SHI SAITAMA, JP, USUDA, SHINJI, USHIKU-SHI IBARAGI, JP, TSUKAMOTO, SHIN-ICHI, ITABASHI-KU TOKYO, JP, HARADA, MASATOMI, OHMIYA-SHI SAITAMA, JP, NAGAOKA, HITOSHI, ITABASHI-KU TOKYO, JP
Format Patent
LanguageGerman
Published 07.09.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Heterocyclic spiro compounds of formula @ @C represents a piperidine ring of which the nitrogene atom may have substituent(s) selected from alkyl, alkanoyl and alkoxycarbonyl and/or may be connected to a ring carbon (other than the common carbon atom of the spiro structure) via an alkylene bridging group; X represents an oxygen of sulfur atom; Y represents a carbonyl group (- @-), a thiocarbonyl group (@@@), a group of the formula @CH-R , a group of the formula or a group of the formula wherein Alk is alkylene and Z and Z are the same or different and selected from oxygen and sulfur atoms; R , R and R are the same of different and selected from a hydrogen atom and alkyl R represents a hydrogen atom or alkyl, carboxy, alkoxycarbonyl, or alkanoyl group; R represents a halogen atom or a hydroxyl, mercapto, alkoxy, alkylthio, alkanoyloxy, or alkanoylthio group; and R and R are the same of different and selected from a hydrogen atom and alkyl groups. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
Bibliography:Application Number: DE19883853758T