Process for the preparation of azolylether ketones

• Main Authors: PERNYESZI, JOZSEF., VESZPREM, HU, SIMON, ZOLTAN, SIMON, KATALIN, GESZTELYI NAGY, ADAM, GESZTELYI NAGY, GEB. BABOCZKY, JUDIT, SZANTO, ANDRAS., BUDAPEST, HU, SZALONTAI, GABOR, KULCSAR, LASZLO, BESAN, JANOS, SZABO, GEB. RAVASZ, BERNADETT, TILINGER, FERENC, VESZPREM, HU, BAGI, LASZLO
• Format: Patent
• Language: English; German
• Published: 15.12.1988
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The application relates to a process for the preparation of azolylether ketones of the general formula I, in which R represents chlorine, bromine, phenyl, alkyl having from 1 to 3 carbon atoms or nitro, R represents alkyl having from 1 to 4 carbon atoms, phenyl or phenyl substituted by chlorine, A represents the grouping = CH- or represents a nitrogen atom, and n represents 0, 1, 2 or 3, where ether ketones of the general formula IV, in which R , R and n have the abovementioned meanings, are reacted, at a temperature of 80-140@C, with equimolar quantities, or at most with a 25 mol% excess, of a halogenating agent, preferably sulphuryl chloride, the haloether ketones, obtained in this way or by any other method, of the general formula II, in which R , R and n have the abovementioned meanings, and X represents chlorine or bromine, are reacted with azoles of the general formula III, in which A has the abovementioned meaning, in a molar ratio of 1:2 at a temperature of 100-180@C, and the azolylether ketones are isolated from the reaction mixture by washing with water or with organic solvents, or by separation.