Verfahren zur Herstellung von L-2-Amino-4-(hydroxymethyl-phosphinyl)-Buttersäure

• Main Authors: KUMADA, YOICHI, IMAI, SATOSHI, TAKANE, NOBUHIKO, MURAKAMI, TAKESHI, SAITO, TOSHINORI, OKADA, AKIRA, YOSHIZAWA, YACHIYO, SATO, ATSUYUKI, HARA, OSAMU, FUKATSU, SHUNZO, TAKABE, HIDEHI, MIYADO, SHINJI, OGAWA, HIROSHI, NAGAOKA, KOZO, ANZAI, HIROYUKI
• Format: Patent
• Language: German
• Published: 02.02.1995
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PROCESSES USING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

A new process of producing L-2-amino-4-(hydroxymethylphosphinyl)-butyric acid (L-AMPB) is now provided, in which 4-(hydroxymethylphosphinyl)-2-oxo-butyric acid (OMPB) is treated with one or more transaminases or with one or more microorganisms capable of producing the transaminase, in the presence of one or more amino-donor compounds such as alpha -amino acids. According to this process, the optically active L-AMPB useful as herbicidal agent can be produced efficiently in a facile way for a reasonable reaction time.