KONDENSIERTE PYRIMIDINDERIVATE MIT EINEM AN DEN PYRIMIDINRING ANKONDENSIERTEN, EIN SCHWEFELATOM AUFWEISENDEN RING, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL SOWIE 2-(HALOGENALKYLENTHIO)- BEZIEHUNGSWEISE 2-(HALOGENVINYLENTHIO)-4,6-DI-(AMINO)-PYRIMIDINE UND VERFAHREN ZUR HERSTELLUNG DER LETZTEREN

The compounds of the general formula I (I) and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I A stands for -CH2-CH2-, -CH2-CH2-CH2-, -CH2-CH2-CH2CH2-or -CH=CH-; R4 is hydrogen, C1-4 a...

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Main Authors MANDI,ATTILA,DR, MAGYAR,KAROLY,DR, POLDERMANN,EDIT,BERENYI,GEB, LAX,GYOERGYI,KOVANYI,GEB, TUBOLY,SANDOR,DR, BOZSING,DANIEL,DR
Format Patent
LanguageGerman
Published 14.07.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The compounds of the general formula I (I) and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy. In the general Formula I A stands for -CH2-CH2-, -CH2-CH2-CH2-, -CH2-CH2-CH2CH2-or -CH=CH-; R4 is hydrogen, C1-4 alkyl or optionally substituted phenyl; r is 0, 1, 2, 3 or 4; R1 stands for hydrogen of C1-5 alkanoyl; R2 represents hydrogen, C1-5 alkanoyl or a group of the general formula (a) (a) wherein R stands for hydrogen, C1-4 alkyl, C2-4 alkenyl, phenyl or phenyl-C1-3 alkyl and R3 stands for hydrogen. The compounds of the general Formula I can be prepared by reacting a 2-mercapto-4,6-diamino-pyrimidine of the general Formula II (II) with a dihalo compound of the general Formula III (III) (wherein Y and Z are halogen).
Bibliography:Application Number: DE19873743935