4H-1-BENZOPYRAN-4-ON-DERIVATE, EIN VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL

The novel 4H-1-benzopyran-4-one derivatives are used as antiinflammatories, analgesics, immunosuppressants and antiallergics. The present invention relates in particular to novel compounds of the formula I in which R1 represents hydrogen, alkyl having 1 to 6 carbon atoms, aryl-C1-C4-alkyl, substitut...

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Main Authors LAXMINARAYAN KATTIGE,SAMBA, NOMANBHAI,DOHADWALLA,ALIHUSSEIN, HELMUT,RUPP,RICHARD, GANAPATI,NAIK,RAMCHANDRA, DE,SOUZA,NOEL JOHN, DAWOODBHAI LAKDAWALLA,AFTAB
Format Patent
LanguageGerman
Published 15.10.1987
Edition4
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The novel 4H-1-benzopyran-4-one derivatives are used as antiinflammatories, analgesics, immunosuppressants and antiallergics. The present invention relates in particular to novel compounds of the formula I in which R1 represents hydrogen, alkyl having 1 to 6 carbon atoms, aryl-C1-C4-alkyl, substituted C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6- cycloalkyl-C1-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl, carboxyl or an aldehyde or COO-C1-C4-alkyl group, R2 represents hydrogen, alkyl having 1 to 6 carbon atoms, nitro, amino, aryl, carboxyl, di-C1-C4- alkylamino, or a halogen, R3 represents C1-C4-alkyl, substituted C1-C4- alkyl, hydroxyl, C1-C4-alkoxy, aryl-C1-C4-alkyl, nitro, amino, a C1-C4- alkyl- or di-C1-C4-alkylamino group or halogen, R4 represents hydrogen, hydroxyl, C1-C4-alkoxy, C1-C4-alkanoyloxy, C1-C4-alkoxycarbonyl, aryloxy, amino or a C1-C4-alkyl- or di-C1-C4-alkylamino group, n represents the integer 0, 1 or 2 and R5 represents hydrogen, C1-C6- alkyl, substituted C1-C6-alkyl, aryl-C1-C4-alkyl, C3-C6-cycloalkyl, C3- C6-cycloalkyl-C1-C4-alkyl, C1-C4-alkanoyl or aroyl, where the aryl group is optionally monosubstituted or polysubstituted phenyl, m denotes an integer between 0 and 3 and n denotes an integer between 0 and 2, and their pharmacologically acceptable acid addition salts.
Bibliography:Application Number: DE19863612337