Proline derivatives

Proline derivatives of the formula I in which R and R can be identical or different and are H, alkyl with 1-4 C atoms or benzyl, R is alkyl with 1-6 C atoms, R is CH3 or -(CH2)4-NH2, R is CH3 or -(CH2)2-Ar, R and R are each H or together are a C-C bond and Ar is phenyl which is unsubstituted or subs...

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Main Authors RADUNZ,HANS-ECKARD,DR, GANTE,JOACHIM,DR, SCHMITGES,CLAUS,DR, OTTO,MINCK,KLAUS, WEBER,WOLF-DIETRICH,DR
Format Patent
LanguageEnglish
German
Published 16.04.1987
Edition4
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Proline derivatives of the formula I in which R and R can be identical or different and are H, alkyl with 1-4 C atoms or benzyl, R is alkyl with 1-6 C atoms, R is CH3 or -(CH2)4-NH2, R is CH3 or -(CH2)2-Ar, R and R are each H or together are a C-C bond and Ar is phenyl which is unsubstituted or substituted one or more times by alkyl with 1-4 C atoms, alkoxy with 1-4 C atoms, Cl and/or CN, and their salts inhibit the effect of angiotensin converting enzyme and lower blood pressure.
Bibliography:Application Number: DE19853536446