VERFAHREN ZUR HERSTELLUNG DES (-)-ANTIPODEN DES (E)-1-CYCLOHEXYL-4,4-DIMETHYL-3-HYDROXY-2-(1,2,4-TRIAZOL-1-YL)-PENT-1-ENS

A process for the preparation of the (-)-antipode of (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene of the formula which comprises reacting the (E)-isomer of 1-cyclohexyl-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one of the formula with lithium aluminum hydride in th...

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Bibliographic Details
Main Authors KRAATZ,UDO,DR, FEYEN,PETER,DR
Format Patent
LanguageGerman
Published 25.09.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the preparation of the (-)-antipode of (E)-1-cyclohexyl-4,4-dimethyl-3-hydroxy-2-(1,2,4-triazol-1-yl)-pent-1-ene of the formula which comprises reacting the (E)-isomer of 1-cyclohexyl-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-pent-1-en-3-one of the formula with lithium aluminum hydride in the presence of an inert organic diluent and in the presence of a chiral aminoalcohol at a temperature between -70 DEG C. and +50 DEG C. The (-)-antipode is produced in high selectivity, using (-)-N-methyl-ephedrine.
Bibliography:Application Number: DE19853509823