PLATIN-DIAMIN-KOMPLEX

This invention relates to a novel platinum-diamine complexes represented by the general formula: wherein R1 and R2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, or jointly...

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Bibliographic Details
Main Authors NAKAYAMA,YUYA, TAKAHASHI,KATSUTOSHI, IWATA,KENJI
Format Patent
LanguageGerman
Published 02.05.1985
Edition3
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to a novel platinum-diamine complexes represented by the general formula: wherein R1 and R2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, or jointly represent a group represented by in which R3 is a lower alkyl group or a group represented by -OM (wherein M is an atom which can become a monovalent cation); Y is -OH or a halogen atom; and n is 0 or 1, and n is 1 when R1 and R2 jointly represent an alkylene group having 5 carbon atoms and X is chlorine. The platinum-diamine complex of this invention has an excellent antitumor activity and a lower renal toxicity than cis-Platin now widely used as a carcinostatic as clinical medicine, and is expected as a carcinostatic lowered in toxicity.
Bibliography:Application Number: DE19843438440