7-AMINO-3(1-PYRIDINIOMETHYL)-8-OXO-5-OXA-1-AZABICYCLO(4.2.0)OCT-2-EN-2-CARBOXYLATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ZWISCHENPRODUKTE ZUR SYNTHESE VON SS-LACTAM-ANTIBIOTIKA

• Main Authors: HARTWIG,WOLFGANG,.DR, HAEBICH,DIETER,.DR
• Format: Patent
• Language: German
• Published: 21.02.1985
• Edition: 3
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

1. Compounds of the general formula (1) see diagramm : EP0135088,P12,F1 in which R represents hydrogen or methoxy, and X and Y, independently of one another, represent the following meanings : hydrogen ; halogen ; cyano ; hydroxyl ; C1 -C4 -alkoxy ; phenoxy ; amino, C1 -C4 -alkylamino, C1 -C4 -dialkylamino or C1 -C4 -alkanoylamino ; carboxyl ; C1 -C4 -alkanoyl ; benzoyl ; phenyl-C1 -C4 -alkanoyl ; C1 -C4 -alkoxycarbonyl ; sulphamoyl ; carbamoyl ; N-C1 -C4 -alkyl-, N,N-C1 -C4 -dialkyl- or N-C1 -C4 -alkoxycarbonylcarbamoyl ; allophanoyl and 4-C1 -C4 -alkylallophanoyl ; C1 -C4 -alkylsulphonyl ; C1 -C4 -alkylthio ; C1 -C6 -alkyl or alkenyl, C3 -C7 -cycloalkyl or cycloalkenyl, phenyl, heterocyclyl having 5- to 6-membered rings and 1 to 4 heteroatoms from the group comprising O, N and/or S, phenylalkyl or heterocyclylalkyl in the above mentioned meaning with 1 to 2 C atoms in the alkyl moiety, each of which is optionally substituted one or more times by hydroxyl, C1 -C4 -alkoxy, halogen, cyano, carboxyl and C1 -C4 -alkoxycarbonyl, C1 -C4 -alkanoyl, C1 -C4 -alkylsulphonyl or -sulphinyl, amino, or mono- or di-C1 -C4 -alkylamino, or C1 -C4 -alkoxyimino, excepting the radicals hydrogen-hydrogen, amino/hydrogen and carbamoyl/hydrogen ; or X and Y together represent a carbocyclic radical which is fused to the pyridine ring in 2.3 or 4.5 position and has 5 - 7 carbon atoms which are optionally replaced by O, S or N heteroatoms.