1,4-DIHYDROPYRIDINE, VERFAHREN ZU IHRER HERSTELLUNG SOWIE IHRE VERWENDUNG IN ARZNEIMITTELN

Novel 1,4-dihydropyridines of the fomula in which R1 and R2 each independently is hydrogen, C1-C4-alkyl, C1-C12-alkoxy, C1-C4-halogenoalkoxy, halogen, nitro, C1-C4-halogenoalkyl, C1-C4-halogenoalkylmercapto, in which Z is oxygen or sulphur, and R4 and R5 each independently is hydrogen, C1-C4-alkyl,...

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Main Authors FRANCKOWIAK,GERHARD,.DR, HEIKER,FRED-ROBERT,.DR, THOMAS,GUENTER,DR, GROSS,RAINER,DR, STOLTEFUSS,JUERGEN, SCHRAMM,MATTHIAS,DR
Format Patent
LanguageGerman
Published 31.01.1985
Edition3
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Novel 1,4-dihydropyridines of the fomula in which R1 and R2 each independently is hydrogen, C1-C4-alkyl, C1-C12-alkoxy, C1-C4-halogenoalkoxy, halogen, nitro, C1-C4-halogenoalkyl, C1-C4-halogenoalkylmercapto, in which Z is oxygen or sulphur, and R4 and R5 each independently is hydrogen, C1-C4-alkyl, C1-C6-alkoxy, halogen, C1-C4-halogenoalkyl, C1-C4-halogenoalkoxy or nitro, or R1 and R2, together with 2 C atoms of the phenyl ring, form the ring X is oxygen, sulphur or the radical NR6, R6 is a C1-C6-alkyl group, A is a C2-C10-alkylene group, it being necessary that at least two C atoms are located in the alkylene chain which connects the carbonyloxy group to X, and R3 is a monosaccharide or disaccharide moiety or a protected monosaccharide or disaccharide moiety, or pharmaceutically acceptable addition salts thereof, which exhibit positive inotropic activity and are useful in treating circulatory disorders.
Bibliography:Application Number: DE19833326384