SUBSTITUIERTE N-ANILINO-4-CHLOR-3-SULFAMOYLBENZAMIDE, IHRE HERSTELLUNG UND PHARMAZEUTISCHE MITTEL

The invention provides substituted N-aniline-4-chloro-3- sulphamoyl benzamides of the general formula I wherein R represents a hydrogen atom or a methyl group and R is a methyl, ethyl, isopropyl, 2- hydroxyethyl or phenyl group and a process for production thereof which comprises acylation of substi...

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Bibliographic Details
Main Authors TRCKA,VACLAV,DR.SC, RAJSNER,MIROSLAV, MACOVA,SVETLUSE,DR, MACHOVA,ALENA,DR, UHLOVA,OTILIE
Format Patent
LanguageGerman
Published 10.03.1983
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides substituted N-aniline-4-chloro-3- sulphamoyl benzamides of the general formula I wherein R represents a hydrogen atom or a methyl group and R is a methyl, ethyl, isopropyl, 2- hydroxyethyl or phenyl group and a process for production thereof which comprises acylation of substituted hydrazines of general formula II with a 4-chloro-3-sulphamoylbenzoyl halide preferably the chloride. Compounds of general formula I have diuretic and saliuretic activity and significant antihypertension effect.
Bibliography:Application Number: DE19823229453