DE3204074

1-Benzyl-4-[4-(2-pyrimidinylamino)benzyl]- 2,3-dioxopiperazine derivatives represented by the formula: wherein R is optionally substituted hydrocarbyl or acyl, R is H or alkyl and X is O or S, and salts thereof have an excellent carcinostatic activity but a low toxicity. Therefore, said compounds ar...

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Main Authors HORI, TAKAKO, TOYAMA, JP, NITTA, JUN, NAMEKAWA, JP, KIBA, YASUO, MURAKAMI, SHOHACHI, KISHIMOTO, SUMIKO, YOSHIDA, CHOSAKU, TAKAOKA, JP, NAKANO, JOJI, TOYAMA, JP, TSUDA, HISATSUGU, TAKENO, RYUKO, SAIKAWA, ISAMU, TOYAMA, JP
Format Patent
LanguageEnglish
Published 23.12.1987
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:1-Benzyl-4-[4-(2-pyrimidinylamino)benzyl]- 2,3-dioxopiperazine derivatives represented by the formula: wherein R is optionally substituted hydrocarbyl or acyl, R is H or alkyl and X is O or S, and salts thereof have an excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.
Bibliography:Application Number: DE19823204074