SS-LACTAM ANTIBIOTIKA, VERFAHREN ZU IHRER HERSTELLUNG SOWIE IHRE VERWENDUNG ALS ARZNEIMITTEL

• Main Authors: BOBERG,MICHAEL,.DR, NAAB,PAUL,.DR, HAEBICH,DIETER,.DR, METZGER,KARL,DR
• Format: Patent
• Language: German
• Published: 24.03.1983
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

A beta -lactam of the formula +TR or a hydrate thereof, in which R represents a hydrogen atom or a methoxy group, n is 1 or 2, Z represents a group of the formula wherein R1 denotes an optionally substituted aryl group or an optionally substituted heterocyclyl group; or, when n is 1, Z can also represent an optionally substituted cycloalkyl group or an optionally substituted pseudoaromatic heterocyclic 5-membered or 6-membered ring, B represents an optionally substituted phenyl or cyclohexadienyl group, or an unsaturated optionally subtituted heterocyclic ring, T denotes an alkyl-CO-O-, pyridinium, aminopyridinium, carbamoylpyridinium or carbamoyloxy group, an -S-phenyl group which can be substituted, or an -S-Het group in which Het represents an optionally substituted heterocyclic 5-membered or 6-membered ring; and E represents a hydrogen atom, a pharmaceutically acceptable ester grouping a salt-forming cation or a protective group, or represents a negative charge when T contains a quaternary nitrogen, which possesses antibacterial activity rendering it useful as an antibiotic and animal feed supplement.