VERFAHREN ZUR HERSTELLUNG VON 2-(AZOMETHIN)-CHINOXALIN-1,4-DIOXYDDERIVATEN UND 2-((AMINO)-(HYDROXY)-METHYL)-CHINOXALIN-1,4-DIOXYDDERIVATE

• Main Authors: PALLOS,LASZLO,DR, MATRAI,ERZSEBET,DR, RATZ,ILDIKO,DR, MAGYAR,KAROLY,DR, BENKO,PAL, KOVACS,JENO,DR, BALOGH,ALBERT
• Format: Patent
• Language: German
• Published: 27.05.1982
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

2-Methylene-1,4-dioxide derivatives of the general formula (I> wherein A represents a hydroxyl or an amino group, or a group of the general formula -NH-COOR1, wherein R1 denotes a C1-4 alkyl group; or a group of the general formula -NH-CX-NH2, wherein X stands for oxygen or sulfur; or a group of the formula -NH-C(=NH)-NH2; or a group of the general formula -NH-R2, wherein R2 represents C1-6 alkyl, phenyl, benzyl, hydroxyl or hydroxy-(C2-4alkyl); or a group of the general formula -NH-CO-R3, wherein R3 stands for a C1-20alkyl group, a phenyl group optionally substituted by one, two or three identical or different substituent(s) selected from the group consisting of hydroxyl, amino, nitro, C1-4alkyl, C1-4 alkoxy or halogen; a piperidyl, a pyridyl, a furyl, a nitrofuryl, a pyrazinyl, a pyrimidyl, a naphthyl, a hydroxynaphthyl, a phenylalkyl, an 1,2,4-triazinyl, an alpha , alpha -diphenyl- alpha - hydroxymethyl, a cyanomethyl, a halomethyl or a hydroxymethyl group, are prepared by dehydrating new compounds of the general formula (II> wherein A has the same meanings as above. The compounds of the general formula (I) possessing bactericidal and weight-gain increasing properties can be obtained in a high purity with an excellent yield by the process according to the invention. A process for the preparation of the new compounds of formula (II) is also disclosed.