BASISCHE 1,7,7-TRIMETHYLBICYCLO(2,2,1)HEPTYLAETHER, VERFAHREN ZUR HERSTELLUNG DERSELBEN UND DIESE ENTHALTENDE ARZNEIMITTEL

• Main Authors: MAGDANYI,LASZLO, KOSOCZKY,IBOLYA,DR, MEZEI,TIBOR, BUDAI,ZOLTAN,DR, PETOECZ,LUJZA,DR, KONYA,ARANKA LAY,GEB, GRASSER,KATALIN,DR
• Format: Patent
• Language: German
• Published: 10.09.1981
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salts thereof, /I/ wherein R1 and R2 may be the same or different and represent a C1-5 alkyl group or a C3-6 cycloalkyl group or they form, together with the adjacent nitrogen atom, a heterocyclic ring containing 4-7 carbon atoms and optionally a further hetero atom, e.g. an oxygen, sulfur or nitrogen atom, and this latter may be optionally substituted by a C1-3 alkyl, benzyl or phenyl group, R represents a phenyl, phenyl-/C1-3 alkyl/ or thienyl group optionally substituted by one or more halogen or C1-3 alkoxy substituent/s/, A represents a C2-5 straight or branched alkylene chain, and represents a valence bond of alpha or beta configuration. The new compounds of the general formula /I/ possess valuable anticonvulsive, motility inhibiting, hexobarbital narcose potentiating and analgesic effects, which are, in case of certain compounds, complemented by week antiserotonine, gastro-intestinal-tract inhibiting and antiinflammatory effects, and can be applied to advantage in the therapy.