4,4-DISUBSTITUIERTE 1,4-DIHYDROPYRIDINE, VERFAHREN ZU IHRER HERSTELLUNG SOWIE IHRE VERWENDUNG IN ARZNEIMITTELN

• Main Authors: BOSSERT,FRIEDRICH,.DR, VATER,WULF,DR, KAZDA,STANISLAV,DR, GOLDMANN,SIEGFRIED,.DR
• Format: Patent
• Language: German
• Published: 21.01.1982
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

1. 4,4-Disubstituted 1,4-dihydropyridines of the general formula (I) see diagramm : EP0042566,P8,F1 in which R represents phenyl,, naphthyl, furyl, pyrryl or pyridyl, these rings optionally containing 1, 2 or 3 identical or different substitutents from the group comprising phenyl, alkyl, alkenyl, alkinyl, alkoxy, alkylene, dioxyalkylene and alkylamino with in each case up to 4 carbon atoms, halogen, trifluoromethyl, trifluoromethoxy, cyano, azido and carboxyamido, R**3 and R**4 are identical or different and each represent hydrogen or an alkyl radical with up to 4 carbon atoms, a phenyl radical or a benzyl radical, R**2 and R**5 are identical or different and each represent a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 6 carbon atoms, can be interrupted in the chain by oxygen and is optionally substituted by halogen, pyridyl, phenyl or phenoxy, it being possible for the phenyl groups in turn to be substituted by halogen, cyano or trifluoromethyl, R**1 represents hydrogen, or a straight-chain, branched or cyclic, saturated or unsaturated aliphatic hydrocarbon radical which has up to 8 carbon atoms, is optionally interrupted in the chain and is optionally substituted by phenyl, phenoxy, pyridyl or amino, the amino group optionally being substituted by two identical or different substitutents from the group comprising alkyl, alkoxyalkyl with in each case up to 4 carbon atoms, phenyl and benzyl, and the phenyl and the phenoxy radical optionally being substituted by halogen, cyano, trifluoromethyl, alkyl, alkoxy or alkylamino with in each case 1 to 4 carbon atoms and n represents 0, 1 or 2, and pharmaceutically acceptable acid addition salts thereof.