VERFAHREN ZUR MIKROBIOLOGISCHEN HERSTELLUNG DES NEBRAMYCIN-KOMPLEXES

In a new process for the microbioglical prodn. of the nebramycin complex, (a) a strain of Streptomyces tenebrarius which biosynthesises the nebramycin complex is cultivated in a nutrient medium contg. nebramycin 2, nebramycin 5' and/or nebramycin 6 and the individuals forming growing aerial myc...

Full description

Saved in:
Bibliographic Details
Main Authors KUN,LAJOS, OTT,ISTVAN,DR, BERDY,JANOS,..DR, FABIAN,FERENC, POLYA,KALMAN,DR, NAGY,CSABA, SZUECS,E, AMBRUS,GABOR,DR, GYIMESI,JOZSEF,..DR, TOELGYESI,LASZLO, VIG,JANOS, KADAR,I, SZELL,VALERIA,DR, HARSANYI,ILONA, NAGY,LASZLO, KASZAB,ISTVAN,DR, ERDEI,JANOS,DR, BALOGH,TIBOR,DR, SZILAGYI,JENOE
Format Patent
LanguageGerman
Published 29.11.1979
Edition2
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPIRITS
SUGARS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:In a new process for the microbioglical prodn. of the nebramycin complex, (a) a strain of Streptomyces tenebrarius which biosynthesises the nebramycin complex is cultivated in a nutrient medium contg. nebramycin 2, nebramycin 5' and/or nebramycin 6 and the individuals forming growing aerial mycelium and spores in the presence of 10-30 mg ml of these antibiotics are isolated; (b) the resulting new resistant strains are cultivated in a submerged aerobic culture in a nutrient medium contg. N- and C- sources, inorganic salts and (opt.) vegetable and/or animal fats at 30-42 degrees C (pref. 35-38 degrees C); and the nebramycin complex or nebramycin 2, nebramycin 4 and nebramycin 5' accumulating in the medium is isolated. Nebramycin 2 (apramycin) is used in the treatment of diseases of animals and plants (cf. US 3691279, 3853709, 3876767). Nebramycin 6 (tobramycin), produced by hydrolysis of nebramycin 5' (6"-O-carbamoyl-tobramycin), is a broad-spectrum antibiotic used in human medicine, esp. against polyresistant Pseudomonas strains. Use of selected nebramycin-resistant Streptomyces tenebrarius strains allows the prodn. of cultures with high nebramycin concns. thus giving improved yields.
Bibliography:Application Number: DE19792921022