ALPHA -HALOGENMETHYLDERIVATE VON AMINOSAEUREN

Novel halomethyl derivatives of amino acids of the following general structure wherein Y is FCH2-, F2CH2-, F3C-, ClCH2-or Cl2CH-; R1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR11R12 wherein each of R11 and R12 is hydrogen or a straight or branched lower alkyl gro...

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Bibliographic Details
Main Authors BEY,PHILIPPE, JUNG,MICHEL
Format Patent
LanguageGerman
Published 08.02.1979
Edition2
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel halomethyl derivatives of amino acids of the following general structure wherein Y is FCH2-, F2CH2-, F3C-, ClCH2-or Cl2CH-; R1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR11R12 wherein each of R11 and R12 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms wherein R5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or wherein R6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each of R3 and R4 is hydrogen, halogen selected from fluorine, chlorine, bromine and iodine, or a straight or branched lower alkyl of from 1 to 4 carbon atoms and may be the same or different with the proviso that when both R3 and R4 are halogen R3 and R4 are the same; and pharmaceutically acceptable salts thereof.
Bibliography:Application Number: DE19782832309