Glucoside hydrolase inhibitors prodn. from bacteria - esp. Bacillus species useful, e.g., for increasing meat yields and feed efficiency

• Main Authors: FROMMER,WERNER,DR, KRAUSE,HANS-PETER,DR, MUELLER,LUTZ,.DR, PULS,WALTER,DR, HEBER,U.,DR, SCHMIDT,DELF,.DR
• Format: Patent
• Language: English; German
• Published: 29.06.1978
• Edition: 2
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FODDER; FOODS OR FOODSTUFFS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The use of microorganisms of the family Bacillaceae to make glucoside-hydrolase inhibitors (I) is new. Pref. species are Bacillus subtilis, B. subtilis var. niger, B. amyloliquefaciens, B. coagulans, B. longisporus and B. polymyxa, specifically the strains DSM 292, 356, 36, 740, 741, 1, 479, 365, 742, 7, 372, 675, 704, 1060, 1061, 1062, 1063, 1064, 1065, 1066 and 1067. The strains DSM 7, 704, 675 and 372 are used to produce 1-deoxynojirimycin. DSM 704, 740, 741, and 742 are claimed as new strains. (I) inhibit saccharase more effectively than known inhibitors; that from DSM 479 also inhibits amylase. When administered to animals they prevent undesirable accumulation of fat, improve feed utilisation and increase the proportion of lean meat. They are also useful in human medicine for treating obesity, hyperglycaemia, constipation etc.