2,2'-Anhydro-1-beta-D-arabinofuranosyl-cytosine salts prepns - obtd by freeze drying aq solns. contg specified additives, for parenteral leukaemia treatment

Freeze-dried prepns. contg. 2,2'-anhydro-1-beta-D-arabinofuranosyl-cytosine salts (I) are prepd. by freeze-drying an aq. soln. of (I) contg. (a) 0.1-6 wt.%, based on (I), of a saccharide, (b) 0.1-6 wt.% of polyvinylpyrrolidone (PVP), (c) 0.1-6 wt.% of sodium carboxymethylcellulose (NaCMC) and/o...

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Main Authors HIKAWA, KENJI, OITA, IKEZUKI, YOSHITAKA, TOKIO, ARAKI, YASUO, SAIKI, OITA, SAIKI, OITA, KOIDE, YOSHIKATSU, NAKAMURA, TOKURO, SEIKI, OITA, ONO, EMIKO
Format Patent
LanguageEnglish
German
Published 11.03.1976
Edition2
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Freeze-dried prepns. contg. 2,2'-anhydro-1-beta-D-arabinofuranosyl-cytosine salts (I) are prepd. by freeze-drying an aq. soln. of (I) contg. (a) 0.1-6 wt.%, based on (I), of a saccharide, (b) 0.1-6 wt.% of polyvinylpyrrolidone (PVP), (c) 0.1-6 wt.% of sodium carboxymethylcellulose (NaCMC) and/or (d) 0.01-0.05 wt.% of a nonionic wetting agent. The products can be used to prepare injectable solns. for use in leukaemia treatment. The prepns. have good storage stability, can be prepd. by conventional rapid freeze-drying, and have a water-solubility of >=1 g/10 ml, forming clear solns.
Bibliography:Application Number: DE19742441761