8-Aminoethyl-4-phenyl-1-thia-4,8-diaza spiro(4,5)decan-3-ones - for protecting the liver against poisoning, treating hepatitis etc

Spiro cpds. of formula (I) and their salts with acids are new: (R = methyl or benzyl). They are prepd. by reacting R2NCH2CH2Y (Y = reactive atom or gp.) with 4-phenyl-1-thia-4,8-diazaspiro 4,5 decan-3-one. This is an Addition to 2255562. (I) and their salts show strong action against liver damage in...

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Main Authors ARIMURA, KATSUO, TSUDA, YOSHIAKI, FUKUOKA, KOBAYAKAWA, TOSHIHIRO, AO, HIDEKI, OITA
Format Patent
LanguageEnglish
German
Published 05.02.1976
Edition2
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract Spiro cpds. of formula (I) and their salts with acids are new: (R = methyl or benzyl). They are prepd. by reacting R2NCH2CH2Y (Y = reactive atom or gp.) with 4-phenyl-1-thia-4,8-diazaspiro 4,5 decan-3-one. This is an Addition to 2255562. (I) and their salts show strong action against liver damage induced by e.g. CCl4 and can be used to treat acute and chronic hepatitis; arrhosis; fatty liver; arteriosclerosis and liver disease caused by ethanol, insecticides derived from organophosphorus cpds., CHCl3, CCl4 etc. They are administered in usual forms, the normal adult dose being 60-120 mg/day.
AbstractList Spiro cpds. of formula (I) and their salts with acids are new: (R = methyl or benzyl). They are prepd. by reacting R2NCH2CH2Y (Y = reactive atom or gp.) with 4-phenyl-1-thia-4,8-diazaspiro 4,5 decan-3-one. This is an Addition to 2255562. (I) and their salts show strong action against liver damage induced by e.g. CCl4 and can be used to treat acute and chronic hepatitis; arrhosis; fatty liver; arteriosclerosis and liver disease caused by ethanol, insecticides derived from organophosphorus cpds., CHCl3, CCl4 etc. They are administered in usual forms, the normal adult dose being 60-120 mg/day.
Author ARIMURA, KATSUO
AO, HIDEKI, OITA
KOBAYAKAWA, TOSHIHIRO
TSUDA, YOSHIAKI, FUKUOKA
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DocumentTitleAlternate 4-PIPERIDINOSPIRANE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIPRAEPARATE
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Snippet Spiro cpds. of formula (I) and their salts with acids are new: (R = methyl or benzyl). They are prepd. by reacting R2NCH2CH2Y (Y = reactive atom or gp.) with...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title 8-Aminoethyl-4-phenyl-1-thia-4,8-diaza spiro(4,5)decan-3-ones - for protecting the liver against poisoning, treating hepatitis etc
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