DE2431178

• Main Authors: SZABO, SUZANNE, LA TOUR DE PEILZ, CH, MAUVERNAY, ROLAND-YVES, RIOM, PUY-DE-DOME, FR, LE VAN, CHAU, MONTHEY, CH, LERIK-MILOVANOVIC, OLGA, BEX, CH, MOLNAR, FRANCOIS, BLONAY, CH, STATKOV, PETER RADANOV, GENF/GENEVE, CH, STRAUMANN, DANIELLE, MARTIGNY, CH
• Format: Patent
• Language: English
• Published: 24.10.1985
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of the formula: R1 R2--C-Q-NN-X-CH=CHI R wherein X represents a carbonyl group C=O or a methylene group -CH2-, R represents a phenyl, mono- or di-halophenyl or 2-pyridyl group, R1 represents a pyridyl or C3-7-cycloalkyl group, R2 represents hydrogen, hydroxy or a C1-5-alkyl group, R3 represents 1 to 3 groups which can be hydrogen, halogen, C1-3-alkyl, methoxy or dioxymethylene, Q represents the (CH2)n group, n having the value 0, 1, 2, 3, the -CH=CH-CH2 - or -O-CH2-CH2- group, HAVE ANALGESIC, HYPOTHERMIC AND ANTI-DEPRESSANT PROPERTIES, ACCOMPANIED BY A WEAK PSYCHOLEPTIC ACTION, ANTICONVULSIVE AND SLIGHTLY SEDATIVE PROPERTIES, VASODILATORY, SPASMOLYTIC, ANTI-BRONCHIOSPASTIC, ANTI-HISTAMINIC, ANTI-ALLERGICAL, ANTI-EMETICAL PROPERTIES, AND WHICH INCREASE THE CEREBRAL AND MYOCARDIC BLOODRATE AND -OXYGENATION.