Amine and amide prepn. by Hofmann degradation - in presence of amine catalysts, polymn. inhibitors and opt. prim. or sec. amines

In the title process amides are reacted with hypohalides in the presence of an excess of an alkaline hydroxide at least equal to 0.2 mole/amide group and cpds. of formula R1R2NK (I) (where R1 is sulphonic, sulphonate or sulphamoyl group; R2 is H, Cl, Br or an aliphatic group and X is H, Cl, or Br; N...

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Main Authors QUADBECK-SEEGER, HANS-JUERGEN. DR., 6700 LUDWIGSHAFEN, TONNE, PETER- . DR., 6730 NEUSTADT
Format Patent
LanguageEnglish
German
Published 17.07.1975
Edition2
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Summary:In the title process amides are reacted with hypohalides in the presence of an excess of an alkaline hydroxide at least equal to 0.2 mole/amide group and cpds. of formula R1R2NK (I) (where R1 is sulphonic, sulphonate or sulphamoyl group; R2 is H, Cl, Br or an aliphatic group and X is H, Cl, or Br; NR1R2 also may be a heterocyclic ring contg. at least one sulphonyl or PO-OR3 group near the M atom and R3 is ' or alkl metal; or R1+R2 is CO-R4-CO and R4 is alkylene, R5 is H, Cl or Br and R6 is an aliphatic group) or a polymn. inhibitorsand opt. a prim. or sec. amine is added at the beginning or during the reaction. Inhibitors may also be catalysts and amines are pref. added after mixing hypohalide with amide. Thus anthranite acid is prepd. from a reaction prod. of phthalic anhydride and ammonia by reaction with naClO (javel water) in the presence of sulphamic acid and NaOH.
Bibliography:Application Number: DE19742400111