ECKIGE KLAMMER AUF ALPHA-(3-TRIFLUORMETHYLPHENOXY)-4-CHLORBENZYL ECKIGE KLAMMER ZU -HETEROCYCLEN

1388790 [Alpha - (3 - trifluoromethylphenoxy) - 4 - chlorobenzyl] - heterocycles MERCK & CO Inc 5 April 1973 16362/73 Heading C2C The invention comprises compounds having the general formula wherein R is a 5-membered heterocycle containing from 2 to 4 hetero atoms, the hetero atoms being oxygen...

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Bibliographic Details
Main Author BOLHOFER, WILLIAM ALFRED, FREDERICK, PA. (V.ST.A.)
Format Patent
LanguageGerman
Published 31.10.1973
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:1388790 [Alpha - (3 - trifluoromethylphenoxy) - 4 - chlorobenzyl] - heterocycles MERCK & CO Inc 5 April 1973 16362/73 Heading C2C The invention comprises compounds having the general formula wherein R is a 5-membered heterocycle containing from 2 to 4 hetero atoms, the hetero atoms being oxygen and/or nitrogen, and non- toxic, pharmaceutically acceptable salts thereof. They may be prepared by cyclizing a compound of the formula wherein R1 is beta-hydroxyethylaminocarbonyl, beta,beta-dichloroethylaminocarbonyl, or iminoazidomethyl. The compounds of the invention reduce the concentration of cholesterol, triglycerides and other lipids in blood serum and are useful in the treatment of atherosclerosis, and may be administered orally or parenterally in admixture with a pharmaceutical diluent or carrier.
Bibliography:Application Number: DE19732318002