DE2313256

• Main Authors: UNO, HITOSHI, TAKATSUKI, HIROOKA, TETSUO, SETTSU, NISHIMURA, HARUKI, IKEDA, OSAKA, KUROKAWA, MIKIO, KOBE, HYOGO, SHIMIZU, MASANAO, KOBE, HYOGO, MASUDA, YOSHINOBU, OSAKA
• Format: Patent
• Language: English
• Published: 12.06.1980
• Edition: 3
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Cpds. of formula (I) and their salts (where R1 = H, halogen, OH, NO2, NH2, C1-5 alkyl or alkoxy; R2= -NHOH, NH2, -NH-NH2, mono- or dialkylamino; aralkylamino, acyloxyamino, morpholino or piperazino (opt. 4-substd. by C1-5 alkyl, aralkyl or aryl) or pyrrolidino; or = imidazoline or tetrahydropyrimidine; n = 0-3). Antidepressants (thymoleptics), hypotensives and anti-parkinsonian agents (potentiators of L-DOPA). EXAMPLE A soln. of 1.58 g. hydroxylamine. HCl and 1.2 g. Na2CO3 in 7.8 ml. H2O is added to a soln. of 3.0 g. 1,2-benzisoxazole-3-acetonitrile in 15 ml. EtOH and heated 3 hrs. to 70 degrees. After the addn. of 7.5 ml. H2O the mixt. is allowed to cool. Yield 3.3 g. 1,2-benzisoxazole-3-acetamidoxime, m.pt. 160-162 degrees (HCl-salt, m.pt. 161-168 degrees).