DE2313256

Cpds. of formula (I) and their salts (where R1 = H, halogen, OH, NO2, NH2, C1-5 alkyl or alkoxy; R2= -NHOH, NH2, -NH-NH2, mono- or dialkylamino; aralkylamino, acyloxyamino, morpholino or piperazino (opt. 4-substd. by C1-5 alkyl, aralkyl or aryl) or pyrrolidino; or = imidazoline or tetrahydropyrimidi...

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Main Authors UNO, HITOSHI, TAKATSUKI, HIROOKA, TETSUO, SETTSU, NISHIMURA, HARUKI, IKEDA, OSAKA, KUROKAWA, MIKIO, KOBE, HYOGO, SHIMIZU, MASANAO, KOBE, HYOGO, MASUDA, YOSHINOBU, OSAKA
Format Patent
LanguageEnglish
Published 12.06.1980
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Cpds. of formula (I) and their salts (where R1 = H, halogen, OH, NO2, NH2, C1-5 alkyl or alkoxy; R2= -NHOH, NH2, -NH-NH2, mono- or dialkylamino; aralkylamino, acyloxyamino, morpholino or piperazino (opt. 4-substd. by C1-5 alkyl, aralkyl or aryl) or pyrrolidino; or = imidazoline or tetrahydropyrimidine; n = 0-3). Antidepressants (thymoleptics), hypotensives and anti-parkinsonian agents (potentiators of L-DOPA). EXAMPLE A soln. of 1.58 g. hydroxylamine. HCl and 1.2 g. Na2CO3 in 7.8 ml. H2O is added to a soln. of 3.0 g. 1,2-benzisoxazole-3-acetonitrile in 15 ml. EtOH and heated 3 hrs. to 70 degrees. After the addn. of 7.5 ml. H2O the mixt. is allowed to cool. Yield 3.3 g. 1,2-benzisoxazole-3-acetamidoxime, m.pt. 160-162 degrees (HCl-salt, m.pt. 161-168 degrees).
Bibliography:Application Number: DE19732313256