DE2263430

• Main Author: HUFFMAN, GEORGE WILLIAM, INDIANAPOLIS, IND., US
• Format: Patent
• Language: English
• Published: 22.09.1983
• Subjects: ADHESIVES; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; DYES; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR; GENERAL PROCESSES OF COMPOUNDING; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; LAUNDERING; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TEXTILES; THEIR PREPARATION OR CHEMICAL WORKING-UP; TREATMENT OF TEXTILES OR THE LIKE; TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS; WORKING-UP

A process for the preparation of halogenated phenylthioacetamido-cephalosporanic acids of general formula ** (See formula) ** where R is ** (See formula) ** where R1 is fluorine or chlorine and when R1 is fluorine, R2 and R4 are hydrogen or chlorine and R3 is hydrogen and when R1 is chlorine a) R2 is hydrogen and one of the radicals R3 or R4 is chlorine, the other being hydrogen or b) R2 is chlorine and R3 and R4 are hydrogen or chlorine and R'is hydrogen, dicyclohexylamine or a pharmaceutically acceptable cation, which process is characterized by acylating 7-aminocephalosporanic acid with an acid of formula ** (See formula) ** or the corresponding anhydride, mixed anhydride, or acyl halide. (Machine-translation by Google Translate, not legally binding)