Biosensor, used in surface plasmon resonance techniques, comprises surface layer of precious metal bound to a hydrogel, a surfactant or biotin layer via monolayer of organic molecules

• Main Authors: WISCHERHOFF, ERIK, NICOLAUS, THOMAS
• Format: Patent
• Language: English; German
• Published: 25.05.2000
• Edition: 7
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING; NANOTECHNOLOGY; PERFORMING OPERATIONS; PHYSICS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TESTING; TRANSPORTING

The biosensor contains a surface layer of precious metal, to which is bound a hydrogel, a surfactant or biotin layer via a monolayer of organic molecules. The biosensor contains a precious metal coating on its surface, to which is bound a hydrogel, a surfactant or biotin layer via a monolayer of organic molecules. The organic molecules are of formula A-R-B. A = an atom or group which binds to the precious metal; R = a hydrocarbon chain with a chain length of up to 10C atoms, which may be interrupted by one or two phenylene groups or heteroatoms; and B = a group that connects the molecule to the surfactant, hydrogel or biotin. An Independent claim is also included for production of the biosensor. Die vorliegende Erfindung betrifft einen Biosensor (Affinitätssensor), bei dem ein Hydrogel, eine Tensidschicht oder Biotin über einen kurzkettigen Linker an die Edelmetalloberfläche des Biosensors gebunden ist und ein Verfahren zu seiner Herstellung. Die vollständige Bedeckung der Biosensoroberfläche mit Hydrogel, einer Tensidschicht oder Biotin wird durch Wasserstoffbrückenbindungen, Aromaten-Aromaten-Wechselwirkungen oder durch kovalente Bindungen erzielt.