Neue Derivate des Tetramethylcyclopropans

PCT No. PCT/US95/01388 Sec. 371 Date Nov. 25, 1996 Sec. 102(e) Date Nov. 25, 1996 PCT Filed Feb. 8, 1995 PCT Pub. No. WO95/21814 PCT Pub. Date Aug. 17, 1995The present invention relates to derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid (TMCA) of general formula (I), (I) wherein R is...

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Main Authors BIALER, MEIR, YAGEN, BORIS, HAJ-YEHIA, ABDULLAH, STERLING, JEFF, HERZIG, YAACOV
Format Patent
LanguageGerman
Published 05.08.2004
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PCT No. PCT/US95/01388 Sec. 371 Date Nov. 25, 1996 Sec. 102(e) Date Nov. 25, 1996 PCT Filed Feb. 8, 1995 PCT Pub. No. WO95/21814 PCT Pub. Date Aug. 17, 1995The present invention relates to derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid (TMCA) of general formula (I), (I) wherein R is lower alkyl group (C1-C6), an aryl group, an aralkyl group or an amide of general formula (II), (II) where R1 and R2 are the same or different and may be hydrogen, a alkyl group (C1-C6), an aryl group or an aralkyl group, and n=0-3, to their racemic mixtures and the D and L enantiomers. The invention also relates to processes for the preparation of said compounds and for pharmaceutical preparations comprising the same. The new compounds show improved activity against epilepsy.
Bibliography:Application Number: DE19951081497T