DE1643273

A polypeptide of formula (I):- Mep = beta-mercaptopropionic acid at posn. 1; D-Arg = D-Arginine at posn. 8 The new polypeptide has greater specific anti-diuretic activity and may be used for the regulation or polyuria and reduction of polydypsia in Diabetes insipidus. R' = benzyl R"= p-tol...

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Bibliographic Details
Main Authors SORM, FRANTISCHEK, ZAORAL, MILAN, PERUCKA, IVAN VAVRA, MACHOVA, ALENA
Format Patent
LanguageEnglish
Published 27.09.1973
Edition1
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A polypeptide of formula (I):- Mep = beta-mercaptopropionic acid at posn. 1; D-Arg = D-Arginine at posn. 8 The new polypeptide has greater specific anti-diuretic activity and may be used for the regulation or polyuria and reduction of polydypsia in Diabetes insipidus. R' = benzyl R"= p-toluenesulfonyl The oxidation is pref. carried out with potassium ferricyanide in aq. solution at pH 6.5-7.0 or in mixtures of water-miscible solvents. Substituents may be used for the protection of the sulfhydryl groups, the amino groups and the guanidine group,.
Bibliography:Application Number: DE19671643273