Producing comb polymers involves providing polyols as backbone, and reacting polyol with amino, ammonium, carboxyl, sulfonyl, sulfonic acid and/or phosphate group-containing compound to form negatively and/or positively charged side chains

• Main Authors: MESZAROS, NINA, WITTMAR, MATTHIAS, MOEWS, KATRIN
• Format: Patent
• Language: English; German
• Published: 29.08.2013
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

Producing comb polymers comprises (a) providing polyols as backbone, (b) partially reacting the polyol with an amino group-containing compound, an ammonium group-containing compound, a carboxyl group-containing compound, a sulfonyl group-containing compound, a sulfonic acid group-containing compound and/or a phosphate group-containing compound to form negatively charged and/or positively charged side chains, and (c) reacting the polyols, provided with negatively charged and/or positively charged side-chains, with hydroxycarboxylic acids and/or its esters to form hydrophobic side-chain. Producing comb polymers comprises (a) providing polyols as backbone, (b) partially reacting the polyol with an amino group-containing compound, an ammonium group-containing compound, a carboxyl group-containing compound, a sulfonyl group-containing compound, a sulfonic acid group-containing compound and/or a phosphate group-containing compound to form negatively charged and/or positively charged side chains, and (c) reacting the polyols, provided with negatively charged and/or positively charged side-chains, with hydroxycarboxylic acids and/or its esters to form hydrophobic side-chain, where the hydroxycarboxylic acids are present as monomers, dimers, oligomers and/or polymers, and the step (c) takes place in the form of a solution polymerization. An independent claim is included for a colloidal nanoparticle, comprising the water-soluble comb polymer and/or an active substance consisting of proteins, preferably insulin, calcitonin, erythropoietin, granulocyte stimulating factor, fibroblast stimulating factor or parathyroid hormone, DNA and its derivatives, somatostatin, cyclosporine and/or prostanoids. Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung eines Kammpolymers, umfassend das Bereitstellen eines Polyols als Rückgrat, das zumindest teilweise Umsetzen des Polyols mit einer Aminogruppen-haltigen Verbindung, einer Ammoniumgruppen-haltigen Verbindung, einer Carboxygruppen-haltigen Verbindung, einer Sulfonylgruppen-haltigen Verbindung, einer Sulfonsäuregruppen-haltigen Verbindung, einer Phosphatgruppen-haltigen Verbindung oder Gemischen davon, um negativ geladene und/oder positiv geladene Seitenketten zu bilden, und das Umsetzen des mit negativ geladenen und/oder positiv geladenen Seitenketten versehenen Polyols mit Hydroxycarbonsäuren und/oder deren Estern in Form einer Lösungspolymerisation, um hydrophobe Seitenketten zu bilden. Die vorliegende Erfindung betrifft ferner ein durch dieses Verfahren erhältliches Kammpolymer sowie kolloidale Nanopartikel, die dieses Kammpolymer enthalten.