New sulfamoylsulfonate prodrugs e.g. useful for protecting red blood cells from attack by parasites or for hormone replacement therapy, female fertility control or treating hormone-associated diseases

• Main Authors: WYRWA, RALF, GANZER, URSULA, NUBBEMEYER, REINHARD
• Format: Patent
• Language: English; German
• Published: 31.05.2007
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

Sulfamoylsulfonate prodrugs (I) are new. Sulfamoylsulfonate prodrugs of formula (I) are new. Drug-O-SO 2-X-SO 2NH 2 (I) X : 1-12C alkanediyl, 1-5C perfluoroalkylene, 3-8C cyloalkanediyl, arylene, heteroalkanediyl, 1-4C alkanediylaryl, (1-4C)alkanediyl(3-8C)cycloalkyl or (3-8C)cycloalkanediyl(1-4C)alkyl; Drug : a pharmaceutical agent capable of forming a sulfonate through an OH group. Independent claims are also included for: (1) pharmaceutical composition comprising a prodrug (I) and another active agent; (2) a process for preparing (I). ACTIVITY : Antiparasitic; Protozoacide; Gynecological; Cytostatic; Antiinflammatory; Antiallergic. MECHANISM OF ACTION : None given. Die Erfindung betrifft Sulfamoylsulfonat-Produgs der allgemeinen Formel I, DOLLAR F1 ein Verfahren zu deren Herstellung, diese Verbindungen enthaltende pharmazeutische Zusammensetzungen und deren Verwendung zur Herstellung oral verfügbarer Arzneimittel. DOLLAR A Die erfindungsgemäßen Verbindungen binden an Carboanhydrasen und hemmen diese Enzyme.