Verfahren zur Herstellung von Diarylcycloalkylderivaten

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful...

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Main Authors JUNKER, BERND, SALAGNAD, CHRISTOPHE, HOLLA, WOLFGANG, STUEDEMANN, THOMAS, MAIER, CLAUS-JUERGEN, KULITZSCHER, BERNDT, MUTTI, STEPHANE, HACHTEL, JOCHEN, HOERLEIN, ROLF-LUDWIG, ZOCHER, FRANK, BURGARD, ANDREAS, TAPPERTZHOFEN, CHRISTOPH
Format Patent
LanguageGerman
Published 11.01.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.
Bibliography:Application Number: DE20041040736