Benzofuran-Derivate

The invention relates to substituted benzofuran derivatives, a method for the production thereof and the use of the same as pharmaceuticals for treating Alzheimer's disease, cardiovascular diseases and diabetes. The effectiveness of the compounds is associated with decreasing serum cholesterol....

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Main Authors MUELLER, ULRICH, JONGHAUS, WILLI, HANING, HELMUT, REINEMER, PETER, BISCHOFF, HILMAR, SCHMIDT, GUNTER, PERNERSTORFER, JOSEF, KRETSCHMER, AXEL, SCHMIDT, DELF, SCHMECK, CARSTEN, VOEHRINGER, VERENA, APELER, HEINER, HAUSWALD, MARTIN, FAESTE, CHRISTIANE, ZOCHE, MARTIN
Format Patent
LanguageGerman
Published 02.10.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to substituted benzofuran derivatives, a method for the production thereof and the use of the same as pharmaceuticals for treating Alzheimer's disease, cardiovascular diseases and diabetes. The effectiveness of the compounds is associated with decreasing serum cholesterol. Said derivatives correspond to formula (I) wherein Z represents O, S, SO, SO2, CH2, CHF, CF2 or NR ; R represents hydrogen or (C1-C4) alkyl; R and the two carbon atoms of the phenyl ring form a saturated or unsaturated furan ring which is optionally identically or differently substituted once or twice; R represents hydrogen or a cation or a group, preferably such as alkyl or acetyl, which can be split under physiological conditions during the formation of an OH function. Die Erfindung betrifft neue Benzofuranderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendungen in Arzneimitteln.
Bibliography:Application Number: DE20011015408