Verwendung von (S)(+)-2-Äthoxy-4-[N-[1-(2-Piperidino-Phenyl)-3-Methyl-1-Butyl[Aminocarbonylmethyl]-Benzoesäure zur Herstellung eines Langzeitantidiabetikums

(S)(+)-2-ethoxy-4-(N-1- (2-piperidino-phenyl)- 3-methyl-1-butyl) aminocarbonylmethyl)- benzoic acid (I), and its salts, are new. The intermediate (S)-3-methyl-1- (2-piperdine-phenyl) -1-butylamine (II) and its amide intermediates of formulae (III), (IV) and (VII) are also new. E.g. (either R = Et an...

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Main Authors GREISCHEL ANDREAS, MARK MICHAEL, KNORR HANSJOERG, GRELL WOLFGANG, MUELLER UELRICH, ZAHN GABRIELE, RUPPRECHT ECKHARD
Format Patent
LanguageGerman
Published 08.01.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:(S)(+)-2-ethoxy-4-(N-1- (2-piperidino-phenyl)- 3-methyl-1-butyl) aminocarbonylmethyl)- benzoic acid (I), and its salts, are new. The intermediate (S)-3-methyl-1- (2-piperdine-phenyl) -1-butylamine (II) and its amide intermediates of formulae (III), (IV) and (VII) are also new. E.g. (either R = Et and A = gp. which can be hydrolysed, thermolysed, hydrogenated or oxidised to carboxy; or R=H and A = carboxy or 1-4C alkyoxy - carbonyl (opt. alkyl substd. by phenyl).
Bibliography:Application Number: DE20001075006C