DIHYDRO-PYRIMIDO-THIAZIN-DERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

• Main Authors: SZECSEY NEE HEGEDUES,MARIA,HU, GACSALY,ISTVAN,HU, TOEMPE,PETER,HU, BOZSING,DANIEL,HU, PETOCZ,LUJZY,HU, GIGLER,GABOR,HU, GYERTYAN,ISTVAN,HU, BENKO,PAL,HU
• Format: Patent
• Language: German
• Published: 19.12.1991
• Edition: 5
• Subjects: APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to new dihydropyrimidothiazine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same and new intermediates useful in the preparation of the said dihydropyrimidothiazine derivatives. The new dihydropyrimidothiazine derivatives of the general formula I, I wherein R1 represents C1-6 alkoxy, amino or phenylamino, R2 stands for C1-6 alkyl or phenyl, R3 represents hydrogen or C1-6 alkyl, and R4 denotes C1-11 alkyl or phenyl optionally bearing one or more identical or different substituent/s/ selected from halogen, nitro, amino, di-(C1-6 alkyl)-amino, C1-6 alkyl, C1-6 alkoxy and hydroxy, and pharmaceutically acceptable acid addition salts thereof exert valuable antianginal and/or antiinflammatory effect/s/ and are useful in therapy.