VERFAHREN ZUR HERSTELLUNG VON NEUEN PYRIDO-3,2-C-AS-TRIAZIN-DERIVATEN

The invention relates to new pyrido[3,2-e]-as-triazine derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof, I wherein R1 stands for a C1-20 alkyl-carbonyl group, halogen-C1-4 alkyl-carbonyl, benzoyl, phenyl-C1-4 alkyl-carbonyl, or pyridyl-carbonyl group; R2 is a...

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Main Authors PETOECZ,LUJZA,HU, HAJOS,GYOERGY,HU, KOSOCZKY,IBOLYA,HU, BENKO,PAL,HU, MESSMER,ANDRAS,HU, GOEROEG,PETER,HU, BATORI,SANDOR,HU
Format Patent
LanguageGerman
Published 24.03.1982
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new pyrido[3,2-e]-as-triazine derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof, I wherein R1 stands for a C1-20 alkyl-carbonyl group, halogen-C1-4 alkyl-carbonyl, benzoyl, phenyl-C1-4 alkyl-carbonyl, or pyridyl-carbonyl group; R2 is a hydrogen atom or a C1-4 alkyl-carbonyl group; or R1 and R2 form together with the adjacent nitrogen atoms a pyrazole-2,4-dione ring which carries a C1-6 alkyl substituent in position 3; R3 is a hydrogen atom, a C1-20 alkyl, phenyl, phenyl-C1-3 alkyl, furyl or pyridyl group or a phenyl group optionally substituted by one to three C1-4 alkoxy-groups. The compounds of the formula I are prepared by acylating the respective 1,2-un-substituted 1,2-dihydropyrido [3,2-e]-as-triazine derivatives. The new compounds exert valuable effects on the central nervous system and possess analgesic, antiphlogistic effects, and can be applied to advantage in therapy.
Bibliography:Application Number: DD19800221352