VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROAZEPIN-,PIPERIDIN-UND PYRROLIDINDERIVATEN

2-Oxo-hexahydroazepine, -piperidine and -pyrrolidine derivatives of general formula (I) where n is 2, 3 or 4, R is hydrogen, lower alkyl or aryl(lower)alkyl and R is hydrogen or lower alkyl are novel intermediates for their aromatised derivatives of formula (II) where n and R are as defined above, R...

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Bibliographic Details
Main Authors CAVALLA,JOHN F.,GB, SHEPHERD,ROBIN G.,GB, WHITE,ALAN C.,GB
Format Patent
LanguageGerman
Published 23.04.1980
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:2-Oxo-hexahydroazepine, -piperidine and -pyrrolidine derivatives of general formula (I) where n is 2, 3 or 4, R is hydrogen, lower alkyl or aryl(lower)alkyl and R is hydrogen or lower alkyl are novel intermediates for their aromatised derivatives of formula (II) where n and R are as defined above, R is hydrogen, lower alkyl or aryl(lower)alkyl and R is hydrogen, lower alkyl, aryl(lower)alkyl, lower alkenyl or lower alkynyl. The aromatised derivatives (of which those in which R is hydrogen are novel) can be converted into 3,3-disubstituted-hexahydroazepine, -piperidine and -pyrrolidine derivatives having pharmacological activity, particularly analgesic activity.
Bibliography:Application Number: DD19780209990