PROCESS FOR PREPARING ESTERS OF 2,6-PYRIDINEDICARBOXYLIC ACIDS
Preparation of 2,6-pyridine-dicarboxylic acid esters of formula (I) comprises reaction of a 2,6-dihalopyridine of formula (II) with carbon monoxide and an alcohol of formula (III) in the presence of a base and a catalyst complex from palladium and a bis-diphenylphosphine derivative of formula (IV)....
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Main Authors | , |
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Format | Patent |
Language | Czech English |
Published |
16.09.1998
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | Preparation of 2,6-pyridine-dicarboxylic acid esters of formula (I) comprises reaction of a 2,6-dihalopyridine of formula (II) with carbon monoxide and an alcohol of formula (III) in the presence of a base and a catalyst complex from palladium and a bis-diphenylphosphine derivative of formula (IV). R1-OH (III). R1 = 1-6C alkyl, 3-6C cycloalkyl, aryl or aralkyl; R2, R3 = H or Cl; R4 = H, 1-6C alkyl, 1-6C alkoxy or F; X = Cl or Br; Q = 3-6C alkanediyl or 1,1'-ferrocenediyl (optionally containing cyclopentadienyl groups substituted by 1-4C alkyl or aryl); R5-R8 = H, 1-4C alkyl, 1-4C alkoxy, CH2F, CHF2, CF3, F, aryl, aryloxy, CN or N(alkyl)2. |
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Bibliography: | Application Number: CZ19980000545 |