Pharmaceutical composition containing water insoluble complex of therapeutically active stable amorphous substance, the complex per se and process for preparing thereof

• Main Authors: SHAH NAVNIT HARGOVINDAS, PHUAPRADIT WANTANEE, ALBANO ANTONIO A, SANDHU HARPREET K
• Format: Patent
• Language: Czech; English
• Published: 18.03.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Farmaceutický prostredek, který obsahuje ve vode nerozpustný komplex terapeuticky úcinné stabilní amorfní látky a ve vode nerozpustného iontového polymeru s molekulovou hmotností vyšší než približne 1,328 432 x 10.sup.-22.n. kg (80 000 D) a s teplotou prechodu do sklovitého stavu približne 50 .degree.C nebo vyšší a nosic; tento nerozpustný komplex; zpusoby prípravy tohoto prostredku a komplexu. Popsaný farmaceutický prostredek podstatne zvyšuje biodostupnost obtížne rozpustných terapeuticky úcinných sloucenin. The present invention provides a pharmaceutical composition comprising water-insoluble complex of a therapeutically effective amount of a stable amorphous substance and an ionic water-insoluble polymer having a molecular weight higher than about 1,328 432 x 10e-22 kg (80 000 D) and with a glass transition temperature equal to or greater than about 50 degC, and a carrier. Disclosed are also the insoluble complex per se and processes for preparing the pharmaceutical composition and the complex. The above-described pharmaceutical composition significantly increases bioavailability of poorly soluble therapeutically active compounds.